Drug interactions
Asenapine + Isradipine
Severity: Moderate
Asenapine and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension, which may be amplified by the vasodilating effect of isradipine. Patients may experience dizziness, syncope or falls, especially at initiation or after dose increases.
What this interaction means in plain words
Asenapine and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-1 blockade (asenapine) and calcium channel blockade (isradipine).
What to do
Monitor blood pressure including orthostatic measurements when starting or adjusting either drug. Counsel patients to rise slowly and reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Isradipine?
MediHelp rates the interaction as moderate. Asenapine and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension, which may be amplified by the vasodilating effect of isradipine. Patients may experience dizziness, syncope or falls, especially at initiation or after dose increases.
How serious is the interaction between Asenapine and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including orthostatic measurements when starting or adjusting either drug. Counsel patients to rise slowly and reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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