Drug interactions
Asenapine + Ketamine
Severity: Moderate
Asenapine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so together they can deepen sedation and impair alertness and coordination. Hypotension may also be additive because asenapine has alpha-blocking activity.
What this interaction means in plain words
Asenapine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive pharmacodynamic effects.
What to do
Monitor level of consciousness, blood pressure and respiration when ketamine is given to a patient taking asenapine. Reduce ketamine doses if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Asenapine and Ketamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Ketamine
Frequently asked questions
Can I take Asenapine with Ketamine?
MediHelp rates the interaction as moderate. Asenapine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so together they can deepen sedation and impair alertness and coordination. Hypotension may also be additive because asenapine has alpha-blocking activity.
How serious is the interaction between Asenapine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of consciousness, blood pressure and respiration when ketamine is given to a patient taking asenapine. Reduce ketamine doses if excessive sedation occurs.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
