Drug interactions
Asenapine + Lamotrigine
Severity: Minor
Asenapine and Lamotrigine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and dizziness, so combined use may increase sedation and impair psychomotor performance. The combination is common in bipolar disorder and is generally well tolerated.
What this interaction means in plain words
Asenapine and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Lamotrigine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through different pharmacodynamic pathways.
What to do
Monitor for daytime drowsiness, especially at initiation or dose increases. Advise caution with driving until the response is known.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Lamotrigine
Frequently asked questions
Can I take Asenapine with Lamotrigine?
MediHelp rates the interaction as minor. Asenapine and Lamotrigine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause somnolence and dizziness, so combined use may increase sedation and impair psychomotor performance. The combination is common in bipolar disorder and is generally well tolerated.
How serious is the interaction between Asenapine and Lamotrigine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daytime drowsiness, especially at initiation or dose increases. Advise caution with driving until the response is known.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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