Drug interactions
Asenapine + Metformin-sitagliptin
Severity: Moderate
Asenapine and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can impair glucose tolerance and raise blood glucose, which may offset the effect of metformin and sitagliptin. Glycemic control may deteriorate, particularly after the antipsychotic is started or the dose is increased.
What this interaction means in plain words
Asenapine and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: atypical antipsychotics cause metabolic effects including insulin resistance and hyperglycemia.
What to do
Check fasting glucose and HbA1c when asenapine is started and periodically afterward. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Asenapine and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can impair glucose tolerance and raise blood glucose, which may offset the effect of metformin and sitagliptin. Glycemic control may deteriorate, particularly after the antipsychotic is started or the dose is increased.
How serious is the interaction between Asenapine and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check fasting glucose and HbA1c when asenapine is started and periodically afterward. Adjust antidiabetic therapy as needed.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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