Drug interactions
Asenapine + Molindone
Severity: Moderate
Asenapine and Molindone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics increases sedation, orthostatic hypotension and extrapyramidal effects, with little evidence of added benefit. Both may also affect QT and seizure threshold.
What this interaction means in plain words
Asenapine and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and dopamine-blocking effects.
What to do
Avoid combined antipsychotic therapy when possible. If both are needed, monitor sedation, blood pressure and movement disorders.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Molindone?
MediHelp rates the interaction as moderate. Asenapine and Molindone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics increases sedation, orthostatic hypotension and extrapyramidal effects, with little evidence of added benefit. Both may also affect QT and seizure threshold.
How serious is the interaction between Asenapine and Molindone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined antipsychotic therapy when possible. If both are needed, monitor sedation, blood pressure and movement disorders.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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