Drug interactions
Asenapine + Nitrous oxide
Severity: Moderate
Asenapine and Nitrous oxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrous oxide has sedative and anesthetic effects and may add to the sedation and hypotension caused by asenapine. The effect is generally short-lived and manageable in monitored settings.
What this interaction means in plain words
Asenapine and Nitrous oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation level and blood pressure during and after nitrous oxide use. Inform the anesthesia or dental team that the patient takes asenapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Nitrous oxide?
MediHelp rates the interaction as moderate. Asenapine and Nitrous oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrous oxide has sedative and anesthetic effects and may add to the sedation and hypotension caused by asenapine. The effect is generally short-lived and manageable in monitored settings.
How serious is the interaction between Asenapine and Nitrous oxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and blood pressure during and after nitrous oxide use. Inform the anesthesia or dental team that the patient takes asenapine.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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