Drug interactions
Asenapine + Olanzapine
Severity: Moderate
Asenapine and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are atypical antipsychotics with some QT-prolonging potential, although olanzapine's effect is generally small. Combining two antipsychotics increases overall adverse effect burden, including sedation, metabolic effects and modest additive QT effects.
What this interaction means in plain words
Asenapine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects, including mild QT prolongation and CNS depression.
What to do
Avoid antipsychotic polypharmacy where possible. If used together, monitor ECG, sedation and metabolic parameters.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Asenapine with Olanzapine?
MediHelp rates the interaction as moderate. Asenapine and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are atypical antipsychotics with some QT-prolonging potential, although olanzapine's effect is generally small. Combining two antipsychotics increases overall adverse effect burden, including sedation, metabolic effects and modest additive QT effects.
How serious is the interaction between Asenapine and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid antipsychotic polypharmacy where possible. If used together, monitor ECG, sedation and metabolic parameters.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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