Drug interactions
Asenapine + Olodaterol inhaled
Severity: Moderate
Asenapine and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine prolongs the QT interval and beta2 agonists can lower potassium and increase heart rate, which may raise arrhythmia risk. Systemic exposure from inhaled olodaterol is low at recommended doses, so the effect is modest.
What this interaction means in plain words
Asenapine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation and beta2-mediated hypokalemia and tachycardia.
What to do
Use olodaterol at the recommended dose and monitor for palpitations. Check ECG and potassium in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Asenapine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine prolongs the QT interval and beta2 agonists can lower potassium and increase heart rate, which may raise arrhythmia risk. Systemic exposure from inhaled olodaterol is low at recommended doses, so the effect is modest.
How serious is the interaction between Asenapine and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use olodaterol at the recommended dose and monitor for palpitations. Check ECG and potassium in patients with other QT risk factors.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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