Drug interactions
Asenapine + Perindopril
Severity: Moderate
Asenapine and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can cause orthostatic hypotension through alpha-1 blockade, which may add to the blood pressure lowering of perindopril. Dizziness, syncope and falls are the main concerns, particularly at initiation.
What this interaction means in plain words
Asenapine and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Perindopril belongs to Cardiovascular.
Why it happens
Additive hypotension from alpha-1 adrenergic antagonism by asenapine and reduced angiotensin II by perindopril.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Lower the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Perindopril?
MediHelp rates the interaction as moderate. Asenapine and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can cause orthostatic hypotension through alpha-1 blockade, which may add to the blood pressure lowering of perindopril. Dizziness, syncope and falls are the main concerns, particularly at initiation.
How serious is the interaction between Asenapine and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing either drug. Lower the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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