Drug interactions
Asenapine + Phenylephrine
Severity: Minor
Asenapine and Phenylephrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine has alpha-1 antagonist activity that can reduce the pressor response to phenylephrine. This may matter when phenylephrine is used to treat hypotension.
What this interaction means in plain words
Asenapine and Phenylephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at alpha-1 adrenergic receptors.
What to do
Titrate phenylephrine to blood pressure response and monitor for reduced effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Phenylephrine?
MediHelp rates the interaction as minor. Asenapine and Phenylephrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Asenapine has alpha-1 antagonist activity that can reduce the pressor response to phenylephrine. This may matter when phenylephrine is used to treat hypotension.
How serious is the interaction between Asenapine and Phenylephrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate phenylephrine to blood pressure response and monitor for reduced effect.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.
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