Drug interactions
Asenapine + Pitolisant
Severity: Major
Asenapine and Pitolisant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant can prolong the QT interval, and asenapine has a similar effect. Combined use may raise the risk of ventricular arrhythmia, and pitolisant labeling advises avoiding other QT-prolonging drugs.
What this interaction means in plain words
Asenapine and Pitolisant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Pitolisant belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Avoid the combination where possible. If both are required, monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Bupropion + Pitolisant Major
- Carbamazepine + Pitolisant Major
Frequently asked questions
Can I take Asenapine with Pitolisant?
MediHelp rates the interaction as major. Asenapine and Pitolisant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pitolisant can prolong the QT interval, and asenapine has a similar effect. Combined use may raise the risk of ventricular arrhythmia, and pitolisant labeling advises avoiding other QT-prolonging drugs.
How serious is the interaction between Asenapine and Pitolisant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are required, monitor ECG and electrolytes.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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