Drug interactions
Asenapine + Prazosin
Severity: Moderate
Asenapine and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block alpha-1 adrenergic receptors, so together they can cause additive hypotension, particularly on standing. This increases the risk of dizziness, syncope and falls, especially at initiation.
What this interaction means in plain words
Asenapine and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Prazosin belongs to Genitourinary.
Why it happens
Additive alpha-1 adrenergic antagonism (pharmacodynamic).
What to do
Monitor supine and standing blood pressure after starting or increasing either drug. Consider reducing the prazosin dose if symptomatic orthostasis occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Asenapine with Prazosin?
MediHelp rates the interaction as moderate. Asenapine and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block alpha-1 adrenergic receptors, so together they can cause additive hypotension, particularly on standing. This increases the risk of dizziness, syncope and falls, especially at initiation.
How serious is the interaction between Asenapine and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure after starting or increasing either drug. Consider reducing the prazosin dose if symptomatic orthostasis occurs.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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