Drug interactions
Asenapine + Promazine
Severity: Moderate
Asenapine and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine is partly metabolized by CYP2D6, and asenapine weakly inhibits this enzyme. Promazine exposure may rise slightly. Both drugs are antipsychotics, so additive sedation, hypotension and QT effects are also possible.
What this interaction means in plain words
Asenapine and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak CYP2D6 inhibition by asenapine, plus additive pharmacodynamic effects of two antipsychotics.
What to do
Avoid combining two antipsychotics where possible. If both are used, monitor sedation, blood pressure and the ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Promazine?
MediHelp rates the interaction as moderate. Asenapine and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine is partly metabolized by CYP2D6, and asenapine weakly inhibits this enzyme. Promazine exposure may rise slightly. Both drugs are antipsychotics, so additive sedation, hypotension and QT effects are also possible.
How serious is the interaction between Asenapine and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two antipsychotics where possible. If both are used, monitor sedation, blood pressure and the ECG.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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