Drug interactions
Asenapine + Protriptyline
Severity: Moderate
Asenapine and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval and cause sedation, so their combination raises the risk of arrhythmia and drowsiness. Protriptyline's anticholinergic and hypotensive effects may add to asenapine's adverse effects.
What this interaction means in plain words
Asenapine and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and additive CNS depressant and anticholinergic effects.
What to do
Check a baseline ECG and electrolytes, and repeat after dose changes. Monitor for sedation, orthostasis and anticholinergic effects, using lower doses where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Protriptyline?
MediHelp rates the interaction as moderate. Asenapine and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QTc interval and cause sedation, so their combination raises the risk of arrhythmia and drowsiness. Protriptyline's anticholinergic and hypotensive effects may add to asenapine's adverse effects.
How serious is the interaction between Asenapine and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and repeat after dose changes. Monitor for sedation, orthostasis and anticholinergic effects, using lower doses where possible.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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