Drug interactions
Asenapine + Quazepam
Severity: Moderate
Asenapine and Quazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam, a benzodiazepine hypnotic, adds to asenapine's sedation and may cause marked drowsiness, impaired coordination and, at higher doses, respiratory depression. Falls and cognitive impairment are of particular concern in older adults.
What this interaction means in plain words
Asenapine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and antipsychotic sedative effects.
What to do
Use the lowest effective doses and monitor sedation and respiratory status, especially at initiation. Avoid combining with other CNS depressants such as alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Quazepam?
MediHelp rates the interaction as moderate. Asenapine and Quazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam, a benzodiazepine hypnotic, adds to asenapine's sedation and may cause marked drowsiness, impaired coordination and, at higher doses, respiratory depression. Falls and cognitive impairment are of particular concern in older adults.
How serious is the interaction between Asenapine and Quazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory status, especially at initiation. Avoid combining with other CNS depressants such as alcohol.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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