Drug interactions
Asenapine + Remifentanil
Severity: Moderate
Asenapine and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is sedating and can cause hypotension, which adds to the respiratory depression and sedation of remifentanil. Effects are generally manageable in monitored settings.
What this interaction means in plain words
Asenapine and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotension from opioid receptor agonism and antipsychotic receptor blockade.
What to do
Titrate remifentanil carefully and monitor sedation, ventilation and blood pressure. Reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Remifentanil?
MediHelp rates the interaction as moderate. Asenapine and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine is sedating and can cause hypotension, which adds to the respiratory depression and sedation of remifentanil. Effects are generally manageable in monitored settings.
How serious is the interaction between Asenapine and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate remifentanil carefully and monitor sedation, ventilation and blood pressure. Reduce doses if excessive sedation occurs.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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