Drug interactions
Asenapine + Reserpine
Severity: Moderate
Asenapine and Reserpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reserpine depletes monoamines and can cause sedation, depression and hypotension, which may add to asenapine's sedative and hypotensive effects. Reserpine may also oppose antipsychotic efficacy and increase extrapyramidal effects.
What this interaction means in plain words
Asenapine and Reserpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotension; reserpine's monoamine depletion overlaps with antipsychotic dopamine blockade.
What to do
Monitor for sedation, orthostatic hypotension, mood changes and movement disorders. Consider an alternative antihypertensive if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Reserpine?
MediHelp rates the interaction as moderate. Asenapine and Reserpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Reserpine depletes monoamines and can cause sedation, depression and hypotension, which may add to asenapine's sedative and hypotensive effects. Reserpine may also oppose antipsychotic efficacy and increase extrapyramidal effects.
How serious is the interaction between Asenapine and Reserpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension, mood changes and movement disorders. Consider an alternative antihypertensive if adverse effects develop.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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