Drug interactions
Asenapine + Sildenafil
Severity: Minor
Asenapine and Sildenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is not an alpha-blocker, but it has alpha-1 antagonist activity and can cause orthostatic hypotension. Combined with sildenafil, additive hypotension is possible but is typically modest.
What this interaction means in plain words
Asenapine and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Asenapine belongs to Central Nervous System; Sildenafil belongs to Genitourinary.
Why it happens
Possible additive hypotensive effect from PDE5 inhibition and the alpha-1 adrenergic antagonism of asenapine.
What to do
Start sildenafil at a low dose and advise the patient to rise slowly. Monitor for dizziness and blood pressure changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Sildenafil?
MediHelp rates the interaction as minor. Asenapine and Sildenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Asenapine is not an alpha-blocker, but it has alpha-1 antagonist activity and can cause orthostatic hypotension. Combined with sildenafil, additive hypotension is possible but is typically modest.
How serious is the interaction between Asenapine and Sildenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sildenafil at a low dose and advise the patient to rise slowly. Monitor for dizziness and blood pressure changes.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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