Drug interactions
Asenapine + Topiramate
Severity: Moderate
Asenapine and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and cognitive slowing, so their combination may increase sedation and impair concentration. Topiramate can also cause psychomotor slowing and word-finding difficulty that add to antipsychotic effects.
What this interaction means in plain words
Asenapine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Topiramate belongs to Central Nervous System.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Monitor for sedation and cognitive effects, particularly during topiramate titration. Advise caution with driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Topiramate
Frequently asked questions
Can I take Asenapine with Topiramate?
MediHelp rates the interaction as moderate. Asenapine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence, dizziness and cognitive slowing, so their combination may increase sedation and impair concentration. Topiramate can also cause psychomotor slowing and word-finding difficulty that add to antipsychotic effects.
How serious is the interaction between Asenapine and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive effects, particularly during topiramate titration. Advise caution with driving until tolerance is established.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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