Drug interactions
Asenapine + Triazolam
Severity: Moderate
Asenapine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a sedating antipsychotic with a short-acting benzodiazepine increases drowsiness, confusion, impaired coordination and the risk of falls. Additive respiratory depression and hypotension may occur, particularly in elderly or frail patients.
What this interaction means in plain words
Asenapine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and the antihistaminic and antiadrenergic sedative effects of asenapine.
What to do
Use the lowest effective triazolam dose for the shortest time and monitor sedation, blood pressure and breathing. Advise against alcohol and caution with driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Triazolam?
MediHelp rates the interaction as moderate. Asenapine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a sedating antipsychotic with a short-acting benzodiazepine increases drowsiness, confusion, impaired coordination and the risk of falls. Additive respiratory depression and hypotension may occur, particularly in elderly or frail patients.
How serious is the interaction between Asenapine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective triazolam dose for the shortest time and monitor sedation, blood pressure and breathing. Advise against alcohol and caution with driving.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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