Drug interactions
Asenapine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Asenapine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can prolong QTc and increase heart rate, and asenapine may add to this. The systemic exposure from inhalation is low, so the risk is mostly relevant in patients with cardiac risk factors.
What this interaction means in plain words
Asenapine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta-adrenergic cardiovascular stimulation.
What to do
Monitor heart rate, symptoms of palpitations and ECG in patients with cardiac disease or other QT risk factors. Ensure potassium is normal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Asenapine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can prolong QTc and increase heart rate, and asenapine may add to this. The systemic exposure from inhalation is low, so the risk is mostly relevant in patients with cardiac risk factors.
How serious is the interaction between Asenapine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, symptoms of palpitations and ECG in patients with cardiac disease or other QT risk factors. Ensure potassium is normal.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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