Drug interactions
Asenapine + Yohimbe
Severity: Moderate
Asenapine and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine in yohimbe is an alpha-2 antagonist that raises sympathetic outflow and can cause hypertension, tachycardia and anxiety or agitation. Asenapine's alpha-blocking properties and effects on psychiatric symptoms may be opposed or destabilised, and the effects are unpredictable.
What this interaction means in plain words
Asenapine and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing pharmacodynamic effects on adrenergic signalling; yohimbine's alpha-2 antagonism increases noradrenergic activity while asenapine has alpha-adrenergic antagonist activity.
What to do
Advise patients to avoid yohimbe products. If used, monitor blood pressure, heart rate and psychiatric symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Asenapine with Yohimbe?
MediHelp rates the interaction as moderate. Asenapine and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine in yohimbe is an alpha-2 antagonist that raises sympathetic outflow and can cause hypertension, tachycardia and anxiety or agitation. Asenapine's alpha-blocking properties and effects on psychiatric symptoms may be opposed or destabilised, and the effects are unpredictable.
How serious is the interaction between Asenapine and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid yohimbe products. If used, monitor blood pressure, heart rate and psychiatric symptoms.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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