Drug interactions
Asenapine transdermal + Clonazepam
Severity: Moderate
Asenapine transdermal and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is a sedating antipsychotic, and with clonazepam it can produce additive drowsiness, dizziness and impaired coordination. Orthostatic hypotension and falls are also more likely, especially in older adults.
What this interaction means in plain words
Asenapine transdermal and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from GABA-A potentiation and antipsychotic receptor antagonism (histamine, alpha-1).
What to do
Use the lowest effective doses and monitor sedation and blood pressure after initiation or dose increases. Counsel patients about driving and fall precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Frequently asked questions
Can I take Asenapine transdermal with Clonazepam?
MediHelp rates the interaction as moderate. Asenapine transdermal and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine is a sedating antipsychotic, and with clonazepam it can produce additive drowsiness, dizziness and impaired coordination. Orthostatic hypotension and falls are also more likely, especially in older adults.
How serious is the interaction between Asenapine transdermal and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and blood pressure after initiation or dose increases. Counsel patients about driving and fall precautions.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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