Drug interactions
Asenapine transdermal + Cyclobenzaprine
Severity: Moderate
Asenapine transdermal and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine is sedating and cyclobenzaprine depresses the CNS, so combined use increases drowsiness and impaired alertness. Orthostatic hypotension and anticholinergic effects may also add up.
What this interaction means in plain words
Asenapine transdermal and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive hypotensive and antimuscarinic effects.
What to do
Monitor for oversedation, dizziness and falls, and adjust doses if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Asenapine transdermal with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Asenapine transdermal and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine is sedating and cyclobenzaprine depresses the CNS, so combined use increases drowsiness and impaired alertness. Orthostatic hypotension and anticholinergic effects may also add up.
How serious is the interaction between Asenapine transdermal and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, dizziness and falls, and adjust doses if excessive sedation occurs.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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