Drug interactions
Asenapine transdermal + Cyproheptadine
Severity: Moderate
Asenapine transdermal and Cyproheptadine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the central nervous system, so combined use can produce more drowsiness, slowed thinking and impaired psychomotor performance. Cyproheptadine's anticholinergic activity may also add to antipsychotic-related anticholinergic effects.
What this interaction means in plain words
Asenapine transdermal and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and histamine H1 and anticholinergic effects.
What to do
Monitor for sedation, confusion and orthostatic symptoms, particularly in older patients. Lower the cyproheptadine dose or choose a less sedating antihistamine if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Asenapine transdermal with Cyproheptadine?
MediHelp rates the interaction as moderate. Asenapine transdermal and Cyproheptadine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the central nervous system, so combined use can produce more drowsiness, slowed thinking and impaired psychomotor performance. Cyproheptadine's anticholinergic activity may also add to antipsychotic-related anticholinergic effects.
How serious is the interaction between Asenapine transdermal and Cyproheptadine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, confusion and orthostatic symptoms, particularly in older patients. Lower the cyproheptadine dose or choose a less sedating antihistamine if needed.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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