Drug interactions
Asenapine transdermal + Morphine
Severity: Moderate
Asenapine transdermal and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an opioid with an antipsychotic such as asenapine can cause additive sedation, hypotension and CNS depression. Respiratory depression is possible, especially in opioid-naive or frail patients.
What this interaction means in plain words
Asenapine transdermal and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects from opioid agonism and antipsychotic antagonism at histaminic, adrenergic and other receptors.
What to do
Start with the lowest effective doses and monitor sedation, respiratory rate and blood pressure. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Asenapine transdermal with Morphine?
MediHelp rates the interaction as moderate. Asenapine transdermal and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an opioid with an antipsychotic such as asenapine can cause additive sedation, hypotension and CNS depression. Respiratory depression is possible, especially in opioid-naive or frail patients.
How serious is the interaction between Asenapine transdermal and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and monitor sedation, respiratory rate and blood pressure. Counsel patients to avoid driving and alcohol.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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