Drug interactions
Asenapine transdermal + Oxazepam
Severity: Moderate
Asenapine transdermal and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause greater drowsiness, dizziness and impaired psychomotor performance. Orthostatic hypotension and falls may also be more likely, especially in older patients.
What this interaction means in plain words
Asenapine transdermal and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation by oxazepam and antipsychotic receptor antagonism by asenapine.
What to do
Monitor for sedation and orthostatic hypotension, particularly at initiation or dose increases. Use the lowest effective benzodiazepine dose and counsel patients about driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Asenapine transdermal with Oxazepam?
MediHelp rates the interaction as moderate. Asenapine transdermal and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause greater drowsiness, dizziness and impaired psychomotor performance. Orthostatic hypotension and falls may also be more likely, especially in older patients.
How serious is the interaction between Asenapine transdermal and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension, particularly at initiation or dose increases. Use the lowest effective benzodiazepine dose and counsel patients about driving and fall risk.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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