Drug interactions
Asenapine transdermal + Paroxetine
Severity: Moderate
Asenapine transdermal and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can prolong the QT interval, and paroxetine has little QT effect on its own, so any additive effect is probably small. Paroxetine inhibits CYP2D6, which contributes to asenapine's clearance, and may raise its levels slightly.
What this interaction means in plain words
Asenapine transdermal and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive QT effects and paroxetine CYP2D6 inhibition modestly increasing asenapine exposure.
What to do
Monitor for sedation, orthostasis and extrapyramidal symptoms. Obtain an ECG in patients with cardiac risk factors or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Asenapine transdermal with Paroxetine?
MediHelp rates the interaction as moderate. Asenapine transdermal and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can prolong the QT interval, and paroxetine has little QT effect on its own, so any additive effect is probably small. Paroxetine inhibits CYP2D6, which contributes to asenapine's clearance, and may raise its levels slightly.
How serious is the interaction between Asenapine transdermal and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostasis and extrapyramidal symptoms. Obtain an ECG in patients with cardiac risk factors or other QT-prolonging drugs.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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