Drug interactions
Asenapine transdermal + Pazopanib
Severity: Moderate
Asenapine transdermal and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib prolongs the QT interval, and asenapine has been associated with QTc prolongation as well. Combined use could increase the risk of ventricular arrhythmias, especially in patients with other risk factors.
What this interaction means in plain words
Asenapine transdermal and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a baseline ECG and electrolytes, and repeat ECG monitoring after starting the combination. Choose an antipsychotic with less QT effect if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Asenapine transdermal with Pazopanib?
MediHelp rates the interaction as moderate. Asenapine transdermal and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib prolongs the QT interval, and asenapine has been associated with QTc prolongation as well. Combined use could increase the risk of ventricular arrhythmias, especially in patients with other risk factors.
How serious is the interaction between Asenapine transdermal and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and repeat ECG monitoring after starting the combination. Choose an antipsychotic with less QT effect if the QTc becomes prolonged.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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