Drug interactions
Acetylsalicylic acid + Azilsartan
Severity: Moderate
Acetylsalicylic acid and Azilsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Analgesic doses of aspirin can reduce the blood pressure lowering effect of angiotensin receptor blockers and may worsen renal function, especially in older or volume-depleted patients. Low-dose aspirin has less effect.
What this interaction means in plain words
Acetylsalicylic acid and Azilsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Azilsartan belongs to Cardiovascular.
Why it happens
Inhibition of renal vasodilatory prostaglandins reduces renal perfusion and antagonizes ARB effect.
What to do
Maintain hydration and monitor blood pressure, serum creatinine and potassium when aspirin is given at analgesic doses. Prefer low-dose aspirin where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Acetylsalicylic acid with Azilsartan?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Azilsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Analgesic doses of aspirin can reduce the blood pressure lowering effect of angiotensin receptor blockers and may worsen renal function, especially in older or volume-depleted patients. Low-dose aspirin has less effect.
How serious is the interaction between Acetylsalicylic acid and Azilsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor blood pressure, serum creatinine and potassium when aspirin is given at analgesic doses. Prefer low-dose aspirin where appropriate.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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