Drug interactions
Amlodipine-perindopril + Azilsartan
Severity: Major
Amlodipine-perindopril and Azilsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perindopril with azilsartan produces dual renin-angiotensin blockade. This raises the risk of hypotension, hyperkalemia and renal impairment without added clinical benefit in most patients.
What this interaction means in plain words
Amlodipine-perindopril and Azilsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-perindopril belongs to Cardiovascular; Azilsartan belongs to Cardiovascular.
Why it happens
Additive inhibition of the renin-angiotensin-aldosterone system by ACE inhibition and angiotensin receptor blockade.
What to do
Avoid combining the two and use one RAS blocker. If unavoidable, monitor potassium, creatinine and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Candesartan Major
Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Azilsartan + Benazepril Major
- Azilsartan + Captopril Major
Frequently asked questions
Can I take Amlodipine-perindopril with Azilsartan?
MediHelp rates the interaction as major. Amlodipine-perindopril and Azilsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Perindopril with azilsartan produces dual renin-angiotensin blockade. This raises the risk of hypotension, hyperkalemia and renal impairment without added clinical benefit in most patients.
How serious is the interaction between Amlodipine-perindopril and Azilsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two and use one RAS blocker. If unavoidable, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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