Drug interactions
Acetylsalicylic acid + Benazepril
Severity: Moderate
Acetylsalicylic acid and Benazepril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin at analgesic or anti-inflammatory doses can blunt the blood pressure lowering effect of ACE inhibitors and may reduce renal function, particularly in older, volume-depleted or renally impaired patients. Low-dose aspirin for cardioprotection generally has little effect.
What this interaction means in plain words
Acetylsalicylic acid and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Benazepril belongs to Cardiovascular.
Why it happens
Inhibition of prostaglandin synthesis reduces renal vasodilation and sodium excretion, opposing ACE inhibitor effects.
What to do
Continue low-dose aspirin when indicated; with higher doses, monitor blood pressure, serum creatinine and potassium and maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Frequently asked questions
Can I take Acetylsalicylic acid with Benazepril?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aspirin at analgesic or anti-inflammatory doses can blunt the blood pressure lowering effect of ACE inhibitors and may reduce renal function, particularly in older, volume-depleted or renally impaired patients. Low-dose aspirin for cardioprotection generally has little effect.
How serious is the interaction between Acetylsalicylic acid and Benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue low-dose aspirin when indicated; with higher doses, monitor blood pressure, serum creatinine and potassium and maintain hydration.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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