Drug interactions
Benazepril + Sacubitril / valsartan
Severity: Contraindicated
Benazepril and Sacubitril / valsartan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitril inhibits neprilysin, which degrades bradykinin, and ACE inhibitors block another bradykinin-degrading pathway. Together they markedly raise the risk of angioedema, which can be life-threatening. Valsartan also adds dual renin-angiotensin blockade.
What this interaction means in plain words
Benazepril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Combined inhibition of neprilysin and ACE causes bradykinin accumulation, with added renin-angiotensin blockade from valsartan.
What to do
Never co-administer. Allow a washout of at least 36 hours when switching between an ACE inhibitor and sacubitril/valsartan in either direction.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benazepril and Sacubitril / valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
- Amlodipine-olmesartan-hydrochlorothiazide + Benazepril Major
Frequently asked questions
Can I take Benazepril with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Benazepril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sacubitril inhibits neprilysin, which degrades bradykinin, and ACE inhibitors block another bradykinin-degrading pathway. Together they markedly raise the risk of angioedema, which can be life-threatening. Valsartan also adds dual renin-angiotensin blockade.
How serious is the interaction between Benazepril and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never co-administer. Allow a washout of at least 36 hours when switching between an ACE inhibitor and sacubitril/valsartan in either direction.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril-valsartan, Amifostine. The full list is on the Benazepril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
