Drug interactions
Acetylsalicylic acid + Cefixime
Severity: Minor
Acetylsalicylic acid and Cefixime: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are acidic and partly cleared by renal tubular secretion, so competition could modestly raise levels of either. Significant clinical consequences are not expected at usual doses.
What this interaction means in plain words
Acetylsalicylic acid and Cefixime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Cefixime belongs to Anti Bacterial.
Why it happens
Competition for renal tubular organic anion transport.
What to do
No dose change is needed. Consider monitoring in patients with significant renal impairment taking high-dose aspirin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Cefixime
- Cefixime + Typhoid vaccine live Major
- Cefixime + Cholera vaccine Moderate
- Cefixime + Kanamycin Moderate
- Cefixime + Microbiota Moderate
- Cefixime + Plazomicin Moderate
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Acetylsalicylic acid with Cefixime?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Cefixime have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are acidic and partly cleared by renal tubular secretion, so competition could modestly raise levels of either. Significant clinical consequences are not expected at usual doses.
How serious is the interaction between Acetylsalicylic acid and Cefixime?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Consider monitoring in patients with significant renal impairment taking high-dose aspirin.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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