Drug interactions
Cefixime + Typhoid vaccine live
Severity: Major
Cefixime and Typhoid vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi replicating in the gut. Cefixime is used to treat typhoid and may reduce vaccine viability and the immune response.
What this interaction means in plain words
Cefixime and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Antibacterial activity inhibits the live attenuated Salmonella strain, reducing immunogenicity.
What to do
Give live oral typhoid vaccine at least 3 days after the last cefixime dose, or vaccinate beforehand. Use the inactivated parenteral vaccine if timing cannot be separated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cefixime
- Cefixime + Cholera vaccine Moderate
- Cefixime + Kanamycin Moderate
- Cefixime + Microbiota Moderate
- Cefixime + Plazomicin Moderate
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Cefixime + Warfarin Moderate
Frequently asked questions
Can I take Cefixime with Typhoid vaccine live?
MediHelp rates the interaction as major. Cefixime and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi replicating in the gut. Cefixime is used to treat typhoid and may reduce vaccine viability and the immune response.
How serious is the interaction between Cefixime and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live oral typhoid vaccine at least 3 days after the last cefixime dose, or vaccinate beforehand. Use the inactivated parenteral vaccine if timing cannot be separated.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Cholera vaccine, Kanamycin, Microbiota. The full list is on the Cefixime page.
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