Drug interactions
Cefixime + Kanamycin
Severity: Moderate
Cefixime and Kanamycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides such as kanamycin are nephrotoxic and ototoxic, and cephalosporins have occasionally been associated with additive renal injury when given alongside them. Cefixime is itself rarely nephrotoxic and is renally cleared, so reduced renal function may raise exposure to both drugs.
What this interaction means in plain words
Cefixime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive nephrotoxicity, with impaired renal function reducing clearance of both agents.
What to do
Monitor serum creatinine and urine output, and consider kanamycin levels and hearing or vestibular symptoms during therapy. Adjust doses to renal function and keep the patient well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefixime
- Cefixime + Typhoid vaccine live Major
- Cefixime + Cholera vaccine Moderate
- Cefixime + Microbiota Moderate
- Cefixime + Plazomicin Moderate
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Cefixime + Warfarin Moderate
Frequently asked questions
Can I take Cefixime with Kanamycin?
MediHelp rates the interaction as moderate. Cefixime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides such as kanamycin are nephrotoxic and ototoxic, and cephalosporins have occasionally been associated with additive renal injury when given alongside them. Cefixime is itself rarely nephrotoxic and is renally cleared, so reduced renal function may raise exposure to both drugs.
How serious is the interaction between Cefixime and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output, and consider kanamycin levels and hearing or vestibular symptoms during therapy. Adjust doses to renal function and keep the patient well hydrated.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Microbiota. The full list is on the Cefixime page.
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