Drug interactions
Acetylsalicylic acid + Celecoxib
Severity: Moderate
Acetylsalicylic acid and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking celecoxib with aspirin raises the risk of gastrointestinal ulceration and bleeding beyond that of either drug alone. Celecoxib may also blunt the cardioprotective antiplatelet benefit of aspirin, and both drugs can impair renal function.
What this interaction means in plain words
Acetylsalicylic acid and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Celecoxib belongs to Musculoskeletal.
Why it happens
Additive inhibition of prostaglandin-mediated gastric mucosal protection and platelet function, with additive renal prostaglandin suppression.
What to do
Avoid the combination where possible; if aspirin is needed for cardiovascular protection, use the lowest effective celecoxib dose for the shortest time and add gastroprotection with a proton pump inhibitor. Monitor for GI bleeding, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Acetylsalicylic acid with Celecoxib?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking celecoxib with aspirin raises the risk of gastrointestinal ulceration and bleeding beyond that of either drug alone. Celecoxib may also blunt the cardioprotective antiplatelet benefit of aspirin, and both drugs can impair renal function.
How serious is the interaction between Acetylsalicylic acid and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if aspirin is needed for cardiovascular protection, use the lowest effective celecoxib dose for the shortest time and add gastroprotection with a proton pump inhibitor. Monitor for GI bleeding, renal function and blood pressure.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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