Drug interactions
Celecoxib + Ketorolac intranasal
Severity: Contraindicated
Celecoxib and Ketorolac intranasal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib with intranasal ketorolac duplicates NSAID therapy; although celecoxib is COX-2 selective, the combination still adds renal and cardiovascular risk and the ketorolac gastrointestinal and bleeding risk remains. Ketorolac labeling prohibits concomitant NSAIDs.
What this interaction means in plain words
Celecoxib and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive cyclooxygenase inhibition producing additive renal, cardiovascular and gastrointestinal toxicity.
What to do
Avoid the combination; use only one NSAID. Use a non-NSAID analgesic for added effect.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
- Betrixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Ketorolac intranasal?
MediHelp rates the interaction as contraindicated. Celecoxib and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Celecoxib with intranasal ketorolac duplicates NSAID therapy; although celecoxib is COX-2 selective, the combination still adds renal and cardiovascular risk and the ketorolac gastrointestinal and bleeding risk remains. Ketorolac labeling prohibits concomitant NSAIDs.
How serious is the interaction between Celecoxib and Ketorolac intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use only one NSAID. Use a non-NSAID analgesic for added effect.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Celecoxib page.
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