Drug interactions
Acetylsalicylic acid + Cilostazol
Severity: Moderate
Acetylsalicylic acid and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit platelet function, so combined use increases the risk of bleeding. The combination is often used deliberately in vascular disease, but the additive effect must be recognized.
What this interaction means in plain words
Acetylsalicylic acid and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Cilostazol belongs to Cardiovascular.
Why it happens
Additive antiplatelet effects through cyclooxygenase inhibition (aspirin) and phosphodiesterase III inhibition (cilostazol).
What to do
Use only when there is a clear indication and keep aspirin at a low dose. Monitor for bleeding and check hemoglobin if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Cilostazol
Frequently asked questions
Can I take Acetylsalicylic acid with Cilostazol?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs inhibit platelet function, so combined use increases the risk of bleeding. The combination is often used deliberately in vascular disease, but the additive effect must be recognized.
How serious is the interaction between Acetylsalicylic acid and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when there is a clear indication and keep aspirin at a low dose. Monitor for bleeding and check hemoglobin if symptoms arise.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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