Drug interactions
Cilostazol + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Major
Cilostazol and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cobicistat component strongly inhibits CYP3A4 and can substantially increase cilostazol exposure. This raises the risk of tachycardia, palpitations, headache and other dose-related adverse effects.
What this interaction means in plain words
Cilostazol and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cobicistat inhibits CYP3A4-mediated cilostazol metabolism.
What to do
Reduce cilostazol to 50 mg twice daily, or choose an alternative agent. Monitor heart rate and cardiovascular symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cilostazol
- Abrocitinib + Cilostazol Major
- Anagrelide + Cilostazol Major
- Betrixaban + Cilostazol Major
- Cilostazol + Cobicistat Major
- Cilostazol + Dalteparin Major
- Cilostazol + Enoxaparin Major
Frequently asked questions
Can I take Cilostazol with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Cilostazol and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The cobicistat component strongly inhibits CYP3A4 and can substantially increase cilostazol exposure. This raises the risk of tachycardia, palpitations, headache and other dose-related adverse effects.
How serious is the interaction between Cilostazol and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce cilostazol to 50 mg twice daily, or choose an alternative agent. Monitor heart rate and cardiovascular symptoms.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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