Drug interactions
Betrixaban + Cilostazol
Severity: Major
Betrixaban and Cilostazol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Betrixaban is a factor Xa inhibitor, and adding cilostazol, an antiplatelet agent, raises the risk of bleeding. Bleeding may be serious, including gastrointestinal bleeding.
What this interaction means in plain words
Betrixaban and Cilostazol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment from anticoagulation plus platelet inhibition.
What to do
Avoid the combination unless clearly necessary; if used, monitor closely for bleeding and hemoglobin changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cilostazol
Frequently asked questions
Can I take Betrixaban with Cilostazol?
MediHelp rates the interaction as major. Betrixaban and Cilostazol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Betrixaban is a factor Xa inhibitor, and adding cilostazol, an antiplatelet agent, raises the risk of bleeding. Bleeding may be serious, including gastrointestinal bleeding.
How serious is the interaction between Betrixaban and Cilostazol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination unless clearly necessary; if used, monitor closely for bleeding and hemoglobin changes.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Cobicistat. The full list is on the Cilostazol page.
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