Drug interactions
Acetylsalicylic acid + Diflunisal
Severity: Moderate
Acetylsalicylic acid and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal is a salicylate derivative, and combining it with aspirin increases the risk of GI bleeding and renal toxicity without added benefit. Aspirin may also lower diflunisal levels.
What this interaction means in plain words
Acetylsalicylic acid and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Diflunisal belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition affecting gastric mucosa, platelets and renal prostaglandins.
What to do
Avoid concurrent use for analgesia; if aspirin is needed for cardioprotection, monitor for GI bleeding and renal function and consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Acetylsalicylic acid with Diflunisal?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal is a salicylate derivative, and combining it with aspirin increases the risk of GI bleeding and renal toxicity without added benefit. Aspirin may also lower diflunisal levels.
How serious is the interaction between Acetylsalicylic acid and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use for analgesia; if aspirin is needed for cardioprotection, monitor for GI bleeding and renal function and consider gastroprotection.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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