Drug interactions
Aspirin + Eprosartan-hydrochlorothiazide
Severity: Moderate
Aspirin and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At analgesic or anti-inflammatory doses, aspirin can reduce the antihypertensive effect of eprosartan and hydrochlorothiazide and increase the risk of renal function decline, particularly in older or volume-depleted patients. Low-dose aspirin for cardiovascular protection has much less effect.
What this interaction means in plain words
Aspirin and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and promotes sodium and fluid retention, opposing ARB and diuretic effects.
What to do
Prefer low-dose aspirin where antiplatelet therapy is needed and avoid regular high-dose use. Monitor blood pressure, creatinine and potassium if higher doses are required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Aspirin with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Aspirin and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At analgesic or anti-inflammatory doses, aspirin can reduce the antihypertensive effect of eprosartan and hydrochlorothiazide and increase the risk of renal function decline, particularly in older or volume-depleted patients. Low-dose aspirin for cardiovascular protection has much less effect.
How serious is the interaction between Aspirin and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer low-dose aspirin where antiplatelet therapy is needed and avoid regular high-dose use. Monitor blood pressure, creatinine and potassium if higher doses are required.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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