Drug interactions
Acetylsalicylic acid + Etodolac
Severity: Major
Acetylsalicylic acid and Etodolac: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining aspirin with etodolac increases the risk of gastrointestinal ulceration and bleeding. Etodolac may also interfere with the antiplatelet effect of low-dose aspirin, reducing cardioprotection, and adds renal risk.
What this interaction means in plain words
Acetylsalicylic acid and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Etodolac belongs to Musculoskeletal.
Why it happens
Additive inhibition of platelet function and gastric prostaglandin synthesis, with possible competition of the NSAID at the platelet COX-1 binding site.
What to do
Avoid routine co-use where possible. If both are needed, add gastroprotection with a proton pump inhibitor and monitor for bleeding and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Alteplase + Etodolac Major
- Amlodipine-olmesartan-hydrochlorothiazide + Etodolac Major
Frequently asked questions
Can I take Acetylsalicylic acid with Etodolac?
MediHelp rates the interaction as major. Acetylsalicylic acid and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining aspirin with etodolac increases the risk of gastrointestinal ulceration and bleeding. Etodolac may also interfere with the antiplatelet effect of low-dose aspirin, reducing cardioprotection, and adds renal risk.
How serious is the interaction between Acetylsalicylic acid and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-use where possible. If both are needed, add gastroprotection with a proton pump inhibitor and monitor for bleeding and renal function.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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