Drug interactions
Etodolac + Ketorolac intranasal
Severity: Contraindicated
Etodolac and Ketorolac intranasal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using etodolac with intranasal ketorolac gives duplicate NSAID therapy, increasing the risk of gastrointestinal bleeding or ulceration, renal impairment and cardiovascular events. Intranasal ketorolac is systemically absorbed and carries the same prohibition on concurrent NSAIDs as the oral form.
What this interaction means in plain words
Etodolac and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive cyclooxygenase inhibition producing additive gastrointestinal, renal, platelet and cardiovascular toxicity.
What to do
Avoid the combination; use a single NSAID. Stop etodolac before starting ketorolac, or choose a non-NSAID analgesic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
- Amlodipine-olmesartan-hydrochlorothiazide + Etodolac Major
Frequently asked questions
Can I take Etodolac with Ketorolac intranasal?
MediHelp rates the interaction as contraindicated. Etodolac and Ketorolac intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Using etodolac with intranasal ketorolac gives duplicate NSAID therapy, increasing the risk of gastrointestinal bleeding or ulceration, renal impairment and cardiovascular events. Intranasal ketorolac is systemically absorbed and carries the same prohibition on concurrent NSAIDs as the oral form.
How serious is the interaction between Etodolac and Ketorolac intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a single NSAID. Stop etodolac before starting ketorolac, or choose a non-NSAID analgesic.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Etodolac page.
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