Drug interactions
Acetylsalicylic acid + Fluoxetine
Severity: Moderate
Acetylsalicylic acid and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine combined with aspirin increases the risk of bleeding, particularly upper gastrointestinal bleeding. The risk is greater in older patients and those with prior ulcers.
What this interaction means in plain words
Acetylsalicylic acid and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Fluoxetine belongs to Central Nervous System.
Why it happens
SSRIs deplete platelet serotonin and impair aggregation, adding to aspirin's antiplatelet effect and gastric mucosal injury.
What to do
Assess GI bleeding risk and consider a proton pump inhibitor in high-risk patients. Advise patients to report black stools, hematemesis or unusual bruising.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Acetylsalicylic acid with Fluoxetine?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine combined with aspirin increases the risk of bleeding, particularly upper gastrointestinal bleeding. The risk is greater in older patients and those with prior ulcers.
How serious is the interaction between Acetylsalicylic acid and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess GI bleeding risk and consider a proton pump inhibitor in high-risk patients. Advise patients to report black stools, hematemesis or unusual bruising.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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