Drug interactions
Aspirin + Gliclazide
Severity: Moderate
Aspirin and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at analgesic or anti-inflammatory doses can enhance the glucose-lowering effect of sulfonylureas such as gliclazide. This may lead to episodes of hypoglycemia, particularly in older patients or those with reduced renal function. Low-dose aspirin for cardioprotection is much less likely to matter.
What this interaction means in plain words
Aspirin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates have intrinsic glucose-lowering activity and may displace sulfonylureas from plasma protein binding, producing additive hypoglycemic effects.
What to do
Monitor blood glucose when starting or stopping regular high-dose aspirin and reduce the gliclazide dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Aspirin with Gliclazide?
MediHelp rates the interaction as moderate. Aspirin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at analgesic or anti-inflammatory doses can enhance the glucose-lowering effect of sulfonylureas such as gliclazide. This may lead to episodes of hypoglycemia, particularly in older patients or those with reduced renal function. Low-dose aspirin for cardioprotection is much less likely to matter.
How serious is the interaction between Aspirin and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping regular high-dose aspirin and reduce the gliclazide dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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