Drug reference
gliclazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Endocrine (Insulin secretagogues)
Mechanism of action
Gliclazide stimulates insulin secretion through the beta cell sulphonylurea receptor, and possibly through a direct effect on intracellular calcium transport. It specifically improves the abnormal first phase insulin release in type 2 diabetes, and also has an effect on the second phase.
Common side effects
- Tremor
- Headache
- Nausea
- Bradycardia
- Hypoglycaemia
Known interactions (5)
- gliclazide + levofloxacin Moderate
- gliclazide + Mirtazapine Moderate
- gliclazide + Nebivolol Moderate
- gliclazide + Sertraline Moderate
- gliclazide + Warfarin Moderate
Related conditions
Frequently asked questions
What drug class is gliclazide?
gliclazide belongs to: Endocrine.
How does gliclazide work?
Gliclazide stimulates insulin secretion through the beta cell sulphonylurea receptor, and possibly through a direct effect on intracellular calcium transport. It specifically improves the abnormal first phase insulin release in type 2 diabetes, and also has an effect on the second phase.
What are the common side effects of gliclazide?
Tremor, Headache, Nausea, Bradycardia, Hypoglycaemia
Which drugs interact with gliclazide?
levofloxacin, Mirtazapine, Nebivolol, Sertraline, Warfarin
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