Drug interactions
Aspirin + Glyburide-metformin
Severity: Moderate
Aspirin and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose aspirin can lower blood glucose and may potentiate sulfonylureas, leading to hypoglycemia. At usual low antiplatelet doses the effect is generally small.
What this interaction means in plain words
Aspirin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates may enhance insulin secretion and displace sulfonylureas from plasma proteins; the exact mechanism is not fully established.
What to do
Monitor blood glucose when regular analgesic or anti-inflammatory doses of aspirin are used. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Aspirin with Glyburide-metformin?
MediHelp rates the interaction as moderate. Aspirin and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose aspirin can lower blood glucose and may potentiate sulfonylureas, leading to hypoglycemia. At usual low antiplatelet doses the effect is generally small.
How serious is the interaction between Aspirin and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when regular analgesic or anti-inflammatory doses of aspirin are used. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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