Drug interactions
Aspirin + Hydrochlorothiazide-telmisartan
Severity: Moderate
Aspirin and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At low cardioprotective doses aspirin has little effect on blood pressure or renal function. At higher analgesic or anti-inflammatory doses it can reduce the effect of telmisartan and hydrochlorothiazide and raise the risk of kidney injury, especially in volume-depleted or elderly patients.
What this interaction means in plain words
Aspirin and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Prostaglandin synthesis inhibition reduces renal blood flow and sodium excretion, which opposes antihypertensive effect and adds to renal hemodynamic stress.
What to do
Low-dose aspirin can usually continue with routine monitoring. With high-dose aspirin, monitor blood pressure, creatinine and potassium and ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Frequently asked questions
Can I take Aspirin with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Aspirin and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At low cardioprotective doses aspirin has little effect on blood pressure or renal function. At higher analgesic or anti-inflammatory doses it can reduce the effect of telmisartan and hydrochlorothiazide and raise the risk of kidney injury, especially in volume-depleted or elderly patients.
How serious is the interaction between Aspirin and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Low-dose aspirin can usually continue with routine monitoring. With high-dose aspirin, monitor blood pressure, creatinine and potassium and ensure adequate hydration.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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